The study is one of many, in humans and in animals, that seek ways to reduce epigenetic-clock scores - and thereby develop new anti-ageing interventions.īut some experts are concerned by the unknowns that still surround this technology. “If you have nine people,” says Horvath, “and you get a statistically significant result, it means there’s a strong effect.” He and the company are now running a randomized and placebo-controlled phase II replication on a larger group of 85 people.
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“Anybody who has an exciting study,” he says, “I love to get involved.”īut critics have questioned the purported decrease in biological age, stressing that it was a small, unblinded study with no placebo control arm. They contacted Steve Horvath, an anti-ageing researcher at the University of California, Los Angeles, to ask if he would use an epigenetic clock to analyse blood samples they had taken during the trial.
Turn back the clock 2019 trial#
In 2017, the scientists behind the growth-hormone trial - based at Intervene Immune, an anti-ageing biotech company in Torrance, California - were excited by their observation of thymus and immune renewal. A technique for measuring biological age detects a signal that is a better guide to a person’s functional capacity than their actual, chronological age.Īs more and more scientists seek to slow, halt or rewind ageing, such methods will be needed to assess whether the new manipulations achieve these goals.Įpigenetic clocks use algorithms to calculate biological age on the basis of a read-out of the extent to which dozens or even hundreds of sites across an individual’s genome are bound by methyl groups - a form of epigenetic modification. Everyone’s physical and mental functioning gradually declines from early adulthood onwards, but this occurs at different rates in different people. They also shaved 2.5 years off the men’s biological age, as measured by one of the most talked-about technologies in ageing research: epigenetic clocks.īiological age is an important concept, albeit a slippery one. The drugs seemed to rejuvenate the men’s thymus glands and immune function.
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Scientists in California gave 9 men aged 51 to 65 a growth hormone and two diabetes medications for a year 1. In 2019, a small study raised the tantalizing prospect that ageing could be reversed.